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Related Concept Videos

Disorders of the Urinary System01:20

Disorders of the Urinary System

The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
Nursing Assessment of the Genitourinary System I: Health History01:21

Nursing Assessment of the Genitourinary System I: Health History

The genitourinary system is critical to maintaining fluid balance, waste elimination, and reproductive function. Nurses play a vital role in assessing this system, beginning with a thorough health history. This process involves gathering patient information, identifying risk factors, and recognizing symptoms of genitourinary disorders. Early detection is vital for timely interventions and management.1. Gathering Patient InformationA complete health history includes the patient’s personal,...
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations01:26

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Urinary Tract Calculi III: Medical Management01:30

Urinary Tract Calculi III: Medical Management

The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...

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Updated: May 31, 2026

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

[Hyperuricemia and uro-nephrological disorders].

Xavier Hurtes1, Paul Meria

  • 1CHRU de Tours, service d'urologie, 37000 Tours, France.

Presse Medicale (Paris, France : 1983)
|June 21, 2011
PubMed
Summary

High uric acid levels (hyperuricemia) increase risks for heart disease and kidney failure. It is linked to kidney stones and metabolic issues like insulin resistance and type 2 diabetes.

Area of Science:

  • Nephrology
  • Cardiology
  • Metabolic Diseases

Background:

  • Hyperuricemia is a significant risk factor for cardiovascular morbidity and mortality.
  • Uric acid lithiasis, a urological condition, is a key symptom of hyperuricemia.
  • Chronic tubular interstitial nephropathy represents the renal manifestation of hyperuricemia.

Purpose of the Study:

  • To highlight the multifaceted risks associated with hyperuricemia.
  • To underscore the connection between hyperuricemia and metabolic syndrome, insulin resistance, and type 2 diabetes.
  • To emphasize hyperuricemia's role as a precursor to chronic renal failure.

Main Methods:

  • Review of existing literature on hyperuricemia and its associated conditions.
  • Analysis of the relationship between uric acid metabolism and uromodulin.

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A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

  • Correlation of hyperuricemia with cardiovascular and renal outcomes.

    • Main Results:

    • Hyperuricemia is directly linked to increased cardiovascular morbidity and mortality.
    • Uric acid lithiasis necessitates investigation for underlying metabolic syndrome, insulin resistance, and type 2 diabetes.
    • Hyperuricemia is a specific risk factor for the development of chronic renal failure and chronic tubular interstitial nephropathy.

    Conclusions:

    • Hyperuricemia poses substantial cardiovascular and renal health risks.
    • Early detection and management of hyperuricemia are crucial for preventing serious complications.
    • Uromodulin plays a role in uric acid metabolism, warranting further investigation.