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Updated: May 31, 2026

Measuring Local Tissue Strains in Tendons via Open-Source Digital Image Correlation
Published on: January 27, 2023
[Area strain: normal values for a new parameter in healthy people].
Leopoldo Pérez de Isla1, Mariángel Millán, Vera Lennie
1Unidad de Imagen Cardiológica, Hospital Carlos III, Instituto Cardiovascular, Madrid, España. leopisla@hotmail.com
This study establishes normal reference values for area strain (AS), a key measure of heart muscle deformation, in healthy individuals. These findings provide a crucial baseline for assessing cardiac function using advanced echocardiography.
Area of Science:
- Cardiology
- Medical Imaging
- Echocardiography
Context:
- Three-dimensional (3D) wall motion tracking is an advanced echocardiographic technique.
- It provides detailed 3D images of the myocardium, enabling comprehensive assessment of cardiac deformation.
- Area strain (AS) is a derived measure combining longitudinal and circumferential deformations of the left ventricle.
Purpose:
- To determine and describe the normal maximum systolic reference values for area strain (AS) in a healthy adult population.
- To establish a baseline for AS measurements in individuals without cardiovascular risk factors or disease.
Summary:
- Sixty healthy subjects were enrolled to measure left ventricular AS using 3D wall motion tracking.
- The overall mean AS value was found to be -38.87 ± 5.89%.
- Mean AS values varied slightly across different myocardial segments: basal (-38.42 ± 7.58%), middle (-38.74 ± 6.34%), and apical (-43.18 ± 12.81%).
Impact:
- This study presents the first reference values for AS in healthy subjects.
- These established norms are essential for accurate interpretation of AS in clinical practice and future research.
- Provides a foundation for utilizing AS as a diagnostic or prognostic biomarker in cardiovascular conditions.
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