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Updated: May 31, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
Natural products as catalysts for innovation: a pharmaceutical industry perspective
Esther K Schmitt1, Charles M Moore, Philipp Krastel
1Natural Products Unit, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Switzerland.
Abstract:
Natural products are evolutionarily designed and chemically distinct from most synthetic library molecules. In addition to their role as drugs, they are successfully used as molecular probes to identify disease relevant targets. Novel natural products are still routinely discovered from traditional sources through cultivation of microorganisms. Complementary approaches based on genome sequence information and subsequent annotation of biosynthetic pathways are emerging technologies. However, to be of practical use for drug discovery, these concepts must be advanced beyond their current state.
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