Related Experiment Video
Updated: May 31, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
Compatibility studies of nateglinide with excipients in immediate release tablets
Nihar Ranjan Pani1, Lila Kanta Nath, Sujata Acharya
1Department of Pharmaceutical Technology, Gayatri College of Pharmacy, Sambalpur, Odisha-768200, India. niharpani@gmail.com
Abstract:
Experiments were done to assess the compatibility of nateglinide with selected excipients in the development of immediate release tablets of nateglinide by thermal and isothermal stress testing (IST) techniques. To evaluate the drug-excipient compatibility, different techniques such as differential scanning calorimetric (DSC) study, infra-red (IR) spectrophotometric study and isothermal stress testing were adopted. The results of DSC study showed that magnesium stearate exhibited some interaction with nateglinide. However, the results of IR, and IST studies showed that all the excipients used in the formula were compatible with nateglinide. Optimized formulations developed using the compatible excipients were found to be stable over 3 months of accelerated stability studies (40 ± 2°C and 75 ± 5% RH). Overall, compatibility of excipients with nateglinide was successfully evaluated using a combination of thermal and IST methods and the formulations developed using the compatible excipients were found to be stable.
Related Concept Videos
Oral Hypoglycemic Agents: Glinides
Modified-Release Drug Delivery Systems: Drug Release Characteristics
Oral Drug Delivery Systems: Continuous-Release Systems
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Modified-Release Drug Delivery Systems: Bioavailability
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

