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Related Concept Videos

RNA Structure01:19

RNA Structure

The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
Protein Folding01:22

Protein Folding

Overview
Protein Folding01:22

Protein Folding

Overview
Protein Folding01:25

Protein Folding

Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...

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Related Experiment Video

Updated: May 31, 2026

RNA Secondary Structure Prediction Using High-throughput SHAPE
13:42

RNA Secondary Structure Prediction Using High-throughput SHAPE

Published on: May 31, 2013

A folding algorithm for extended RNA secondary structures.

Christian Höner zu Siederdissen1, Stephan H Bernhart, Peter F Stadler

  • 1Institute for Theoretical Chemistry, University of Vienna, A-1090 Vienna, Austria. choener@tbi.inivie.ac.at

Bioinformatics (Oxford, England)
|June 21, 2011
PubMed
Summary
This summary is machine-generated.

This study introduces a new theoretical model for RNA secondary structure prediction, improving accuracy by accounting for non-canonical base pairs and extended motifs. The RNA structure prediction software is publicly available.

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Area of Science:

  • Computational Biology
  • Bioinformatics
  • Structural Biology

Background:

  • RNA secondary structures feature diverse non-canonical base pairs.
  • Accurate prediction of these features enhances secondary structure modeling.
  • Improved models have applications in tertiary structure prediction and RNA folding/alignment.

Purpose of the Study:

  • To present a novel theoretical model for RNA secondary structure.
  • To incorporate non-canonical base pairs and extended secondary structure motifs.
  • To provide accompanying software for parameter optimization and structure prediction.

Main Methods:

  • Development of a theoretical model using 2-diagrams.
  • Implementation of programs for parameter optimization.
  • Implementation of programs for RNA structure prediction.

Main Results:

  • A theoretical model capturing diverse RNA pair families and extended motifs with shared nucleotides was developed.
  • The model utilizes 2-diagrams for representation.
  • Associated software tools for optimization and prediction are provided.

Conclusions:

  • The developed model and software advance RNA secondary structure prediction.
  • The inclusion of non-canonical pairs and extended motifs improves structural accuracy.
  • The software is publicly available under GPLv3 for broader research use.