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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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Autoimmune Disorders

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Concept and Mechanism of Autoimmune Diseases
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Related Experiment Video

Updated: May 31, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Late-age onset systemic sclerosis.

Rebecca L Manno1, Fredrick M Wigley, Allan C Gelber

  • 1Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.

The Journal of Rheumatology
|June 21, 2011
PubMed
Summary
This summary is machine-generated.

Older adults with systemic sclerosis (SSc) face higher risks for pulmonary hypertension, renal impairment, cardiac disease, and muscle weakness. Early detection and management are crucial for this patient group.

Related Experiment Videos

Last Updated: May 31, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

  • Rheumatology
  • Geriatrics
  • Internal Medicine

Background:

  • Systemic sclerosis (SSc) can affect patients at any age.
  • Late-age onset SSc (≥ 65 years) may present with distinct clinical characteristics.
  • Understanding organ-specific risks in older SSc patients is vital for tailored care.

Purpose of the Study:

  • To investigate differences in organ manifestation risks between late-age onset and early-age onset SSc.
  • To compare demographic and clinical features of these two SSc patient groups.
  • To inform clinical management strategies for older SSc patients.

Main Methods:

  • Retrospective analysis of 2300 SSc patients from a university-based cohort (1990-2009).
  • Comparison of demographic profiles, SSc subtypes, autoantibodies, and Medsger severity scores.
  • Evaluation of pulmonary function, echocardiography, and right heart catheterization data.

Main Results:

  • Late-age onset SSc patients showed higher rates of anticentromere antibodies.
  • Increased risk of pulmonary hypertension, muscle weakness, renal impairment, and cardiac disease in older SSc patients.
  • Reduced risk of digital ischemia observed in the late-age onset group.

Conclusions:

  • Older patients with SSc exhibit a significantly greater risk for pulmonary hypertension, renal impairment, cardiac disease, and muscle weakness.
  • Pulmonary hypertension risk is notably higher in late-onset SSc, with a 5-year cumulative incidence of 9% vs. 2.7%.
  • Clinical awareness of these distinct organ risks is essential for managing SSc patients diagnosed after age 65.