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Related Experiment Video

Updated: May 31, 2026

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

Published on: April 28, 2023

A 7-d exercise program increases high-molecular weight adiponectin in obese adults.

Karen R Kelly¹, Alecia Blaszczak, Jacob M Haus

¹Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

Medicine and Science in Sports and Exercise

|June 21, 2011

Summary

Seven days of vigorous exercise significantly boosted high-molecular weight adiponectin (HMW adiponectin) and improved insulin sensitivity in obese individuals. This short-term exercise intervention also enhanced fat oxidation, independent of body weight changes.

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Published on: July 17, 2018

Area of Science:

Endocrinology
Metabolic Health
Exercise Physiology

Background:

High-molecular weight adiponectin (HMW adiponectin) is crucial for insulin sensitivity and metabolic function.
Previous research indicated that 7 days of exercise improves insulin sensitivity in obese individuals.
The impact of short-term exercise training on HMW adiponectin in obese populations remained unclear.

Purpose of the Study:

To investigate the effect of a 7-day supervised vigorous exercise program on HMW adiponectin and leptin secretion in obese individuals.
To assess the impact of this short-term exercise intervention on insulin sensitivity, body composition, and fat oxidation.

Main Methods:

Seventeen obese individuals underwent 7 consecutive days of supervised vigorous exercise (60 min/day at 85% HRmax).
Insulin sensitivity was measured using the Matsuda Index from an oral glucose tolerance test (OGTT).
Fasting plasma HMW adiponectin and leptin levels were quantified, alongside body composition (DXA) and fat oxidation (indirect calorimetry).

Main Results:

A significant increase in fasting HMW adiponectin levels was observed post-intervention (P=0.02).
Leptin levels decreased significantly (P=0.03), and insulin sensitivity (ISIOGTT) improved (P=0.04).
Increased HMW adiponectin correlated positively with enhanced basal fat oxidation (r=0.57, P=0.03).

Conclusions:

Seven days of vigorous exercise is sufficient to improve insulin sensitivity and fat oxidation in obese individuals.
This short-term exercise regimen favorably alters adipokine secretion, including HMW adiponectin.
These metabolic improvements occurred independently of significant changes in body weight or composition.