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Updated: May 31, 2026

Asymmetric Walkway: A Novel Behavioral Assay for Studying Asymmetric Locomotion
Published on: January 15, 2016
Random walk with barriers
Dmitry S Novikov1, Els Fieremans, Jens H Jensen
1Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY 10016, USA.
Abstract:
Restrictions to molecular motion by barriers (membranes) are ubiquitous in porous media, composite materials and biological tissues. A major challenge is to characterize the microstructure of a material or an organism nondestructively using a bulk transport measurement. Here we demonstrate how the long-range structural correlations introduced by permeable membranes give rise to distinct features of transport. We consider Brownian motion restricted by randomly placed and oriented membranes (d - 1 dimensional planes in d dimensions) and focus on the disorder-averaged diffusion propagator using a scattering approach. The renormalization group solution reveals a scaling behavior of the diffusion coefficient for large times, with a characteristically slow inverse square root time dependence for any d. Its origin lies in the strong structural fluctuations introduced by the spatially extended random restrictions, representing a novel universality class of the structural disorder. Our results agree well with Monte Carlo simulations in two dimensions. They can be used to identify permeable barriers as restrictions to transport, and to quantify their permeability and surface area.
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