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Related Concept Videos

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What is Evolutionary History?

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During the 1950s, the landmark Robbers Cave experiment demonstrated that when groups must compete with one another, intergroup conflict, hostility, and even violence may result. At the Oklahoman summer camp, two troops of boys—termed the Rattlers and the Eagles—took part in a week-long tournament. During this time, their negativity culminated in derogatory name-calling, fistfights, and even vandalism and destruction of property. However, this work also revealed that such tension could be...
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Related Experiment Video

Updated: May 31, 2026

JenaTron - An Experimental Approach to Study the Effects of Plant History and Soil History on Grassland Ecosystem Functioning
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Ras history: The saga continues.

Adrienne D Cox1, Channing J Der

  • 1Department of Radiation Oncology; Lineberger Comprehensive Cancer Center; University of North Carolina at Chapel Hill; Chapel Hill, NC USA.

Small Gtpases
|June 21, 2011
PubMed
Summary

Research into Ras genes, discovered in human cancer in 1982, has advanced molecular cancer origins, cell signaling, and small GTPase biology. These findings are foundational for developing anti-Ras cancer drugs.

Area of Science:

  • * Molecular oncology: Understanding cancer at the gene level.
  • * Cellular biology: Elucidating signal transduction pathways.
  • * Protein biochemistry: Characterizing small GTPases and their cellular roles.

Background:

  • * Ras research originated from retrovirus studies.
  • * Discovery of mutationally activated RAS genes in human cancer in 1982 spurred intensive investigation.
  • * Focus on Ras protein structure, biochemistry, and biology.

Purpose of the Study:

  • * To review key findings in Ras research over 28 years.
  • * To highlight the foundational impact of Ras discoveries on three broad scientific areas.
  • * To underscore the ultimate goal of developing anti-Ras cancer therapies.

Main Methods:

  • * Literature review and synthesis of key findings in Ras research.

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  • * Analysis of the impact of Ras discoveries on cancer genetics, signal transduction, and GTPase biology.
  • * Highlighting foundational concepts and discoveries over a 28-year period.

    • Main Results:

    • * Ras research has led to the discovery of thousands of cancer-associated genes.
    • * Elucidation of Ras-mediated signal transduction established fundamental concepts of cellular communication.
    • * Ras proteins identified as founding members of the small GTPase superfamily, crucial for cellular processes.

    Conclusions:

    • * Ras research has profoundly impacted molecular oncology, cell signaling, and GTPase biology.
    • * Discoveries have laid the groundwork for understanding cancer at a molecular level.
    • * Continued research aims to translate these findings into effective anti-Ras cancer treatments.