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Apoplast-Extraction Based Method to Improve the Purity of Plant Produced Recombinant Protein

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Evolution of plant-made pharmaceuticals.

David R Thomas¹, Claire A Penney, Amrita Majumder

¹School of Biological Sciences, Monash University, Clayton, Victoria 3800, Australia; E-Mails: david.r.thomas@monash.edu (D.R.T.); claire.penney@monash.edu (C.A.P.); amrita.majumder@monash.edu (A.M.).

International Journal of Molecular Sciences

|June 21, 2011

Summary

Plant-made pharmaceuticals have advanced from basic remedies to regulated products, with several purified plant-based drugs now in Phase II trials. This progress, though slow, marks a significant step towards consumer availability for these innovative medicines.

Keywords:

expression system plant-made recombinant protein

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Area of Science:

Biotechnology
Pharmaceutical Sciences
Plant Molecular Farming

Background:

The field of plant-made pharmaceuticals has evolved significantly over 21 years.
Early development faced challenges, with plant-made vaccines stalling in Phase I trials.
The transition from backyard remedies to regulated, purified products signifies maturation.

Observation:

Several purified plant-based pharmaceutical products have advanced beyond Phase I to Phase II clinical trials.
Despite inherent difficulties in pharmaceutical development, plant-made products are achieving key milestones.
Progress in plant-made pharmaceuticals has been slower compared to other production systems.

Findings:

Plant-made pharmaceuticals demonstrate a paradigm shift from early-stage research to advanced clinical development.
Developmental timelines show a recent acceleration, moving multiple products into later trial phases.
The technology is nearing consumer-ready products, overcoming previous developmental bottlenecks.

Implications:

Continued investment and strategic planning are crucial to maintain momentum in plant-made pharmaceutical technology.
This field offers a promising alternative production system for pharmaceuticals.
Understanding the current status and future potential is vital for guiding future research and development efforts.