Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
Diabetic Ketoacidosis ll: Pathophysiology01:22

Diabetic Ketoacidosis ll: Pathophysiology

Diabetic ketoacidosis (DKA) is a metabolic emergency characterized by hyperglycemia, ketonemia, and metabolic acidosis. It results from severe insulin deficiency and an excess of counterregulatory hormones, leading to uncontrolled lipolysis, ketogenesis, and widespread electrolyte and fluid disturbances.Pathophysiology The central event in DKA is a profound loss of insulin action. Without insulin, glucose uptake in insulin-dependent tissues is impaired, while hepatic glucose production...
Diabetic Ketoacidosis l: Introduction01:25

Diabetic Ketoacidosis l: Introduction

DefinitionDiabetic ketoacidosis (DKA) is an acute, life-threatening complication of diabetes mellitus, characterized by a triad of hyperglycemia (blood glucose >250 mg/dL), ketonemia or ketonuria, and metabolic acidosis (arterial pH <7.30 and serum bicarbonate <18 mEq/L). It results from insulin deficiency combined with elevated levels of counterregulatory hormones—glucagon, catecholamines, cortisol, and growth hormone—leading to increased lipolysis, hepatic ketone production, and...
Overview of Protein Metabolism01:21

Overview of Protein Metabolism

Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The efficacy of progestins in managing pain associated with endometriosis, fibroids and pre-menstrual syndrome: a systematic review.

Archives of gynecology and obstetrics·2025
Same author

Re: The Hayman uterine compression suture.

BJOG : an international journal of obstetrics and gynaecology·2015
Same author

Delayed postpartum haemorrhage secondary to a ruptured uterine artery pseudo-aneurysm, successfully treated by transarterial embolisation.

BMJ case reports·2012
Same author

Papulonecrotic tuberculids: a rare cutaneous manifestation of tuberculosis in pregnancy.

BMJ case reports·2011
Same author

Anemia and pregnancy: a link to maternal chronic diseases.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2011
Same author

The B-Lynch uterine brace suture, and a bit of this and a bit of that...

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2010

Related Experiment Video

Updated: May 31, 2026

Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells
09:40

Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells

Published on: June 20, 2018

Ketonuria and HELLP syndrome.

Phanendra Kumar Gubbala1, Mahantesh Karoshi, Faris Zakaria

  • 1Flat 170, Marine Court, St Leonards on Sea, East Sussex TN38 0DZ, UK.

BMJ Case Reports
|June 21, 2011
PubMed
Summary

HELLP syndrome, a serious condition causing hemolysis, elevated liver enzymes, and low platelets, can be misdiagnosed due to vague symptoms like gastroenteritis. Early clinical suspicion is crucial for timely diagnosis and management to prevent maternal complications.

Area of Science:

  • Obstetrics and Gynecology
  • Hematology
  • Critical Care Medicine

Background:

  • HELLP syndrome (Hemolysis, Elevated Liver enzymes, Low Platelets) is a severe obstetric complication.
  • Delayed diagnosis of HELLP syndrome can lead to significant maternal morbidity and mortality.
  • Gastroenteritis-like symptoms can mask the presentation of HELLP syndrome.

Purpose of the Study:

  • To highlight the diagnostic challenges in HELLP syndrome.
  • To emphasize the importance of clinical vigilance in managing HELLP syndrome.
  • To underscore the varied symptomatology that can obscure HELLP syndrome diagnosis.

Main Methods:

  • Case report of a patient with HELLP syndrome.
  • Review of diagnostic challenges and clinical presentation.

Related Experiment Videos

Last Updated: May 31, 2026

Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells
09:40

Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells

Published on: June 20, 2018

  • Discussion of management strategies for HELLP syndrome.
  • Main Results:

    • A case of HELLP syndrome was initially misdiagnosed due to overlapping symptoms with gastroenteritis.
    • The patient's presentation demonstrated the varied and sometimes absent typical symptoms of HELLP syndrome.
    • Diagnostic delay was attributed to the atypical presentation and lack of initial high suspicion.

    Conclusions:

    • Clinical vigilance and a high index of suspicion are paramount for the early diagnosis of HELLP syndrome.
    • Recognizing the diverse clinical presentations of HELLP syndrome is essential for prompt management.
    • Timely diagnosis and management of HELLP syndrome are critical to reduce maternal morbidity and mortality.