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Updated: May 31, 2026

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
Acute hepatitis induced by glatiramer acetate
Pierre Deltenre1, Marie-Odile Peny, André Dufour
1Hopital de Jolimont, Service d'Hépato-gastroentérologie, Rue Ferrer, 159, Haine-Saint-Paul, 7100, Belgium.
Abstract:
Glatiramer acetate, a mixture of synthetic polypeptides able to prevent autoimmune encephalomyelitis in experimental models, is used as a treatment for patients with active relapsing-remitting multiple sclerosis. We report one case of glatiramer acetate induced hepatitis. Liver biopsy was consistent with a diagnosis of drug induced hepatitis and alanine aminotransferase returned to normal values after treatment discontinuation. The present case should serve as a warning that glatiramer acetate may cause acute liver disease.
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