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Related Experiment Video

Updated: May 31, 2026

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

Acute hepatitis induced by glatiramer acetate.

Pierre Deltenre¹, Marie-Odile Peny, André Dufour

¹Hopital de Jolimont, Service d'Hépato-gastroentérologie, Rue Ferrer, 159, Haine-Saint-Paul, 7100, Belgium.

BMJ Case Reports

|June 21, 2011

Summary

Glatiramer acetate, used for multiple sclerosis, may cause drug-induced hepatitis. This case highlights the potential for acute liver injury, emphasizing the need for monitoring during treatment.

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Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

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Published on: May 29, 2020

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Area of Science:

Immunology
Hepatology
Neurology

Background:

Glatiramer acetate is a disease-modifying therapy for relapsing-remitting multiple sclerosis.
It is a synthetic polypeptide mixture known for its immunomodulatory properties.
Autoimmune encephalomyelitis is a relevant experimental model for multiple sclerosis.

Purpose of the Study:

To report a case of glatiramer acetate-induced hepatitis.
To highlight the potential for acute liver injury associated with this multiple sclerosis treatment.

Main Methods:

Case report detailing a patient experiencing adverse liver effects.
Liver biopsy performed for diagnostic confirmation.
Monitoring of alanine aminotransferase levels before and after treatment cessation.

Main Results:

The patient developed drug-induced hepatitis.
Liver biopsy findings were consistent with drug-induced liver injury.
Alanine aminotransferase levels normalized after discontinuing glatiramer acetate.

Conclusions:

Glatiramer acetate can induce acute liver disease.
Physicians should be aware of this potential adverse effect.
Monitoring liver function is crucial in patients treated with glatiramer acetate.