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Updated: May 31, 2026

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
Published on: October 27, 2020
Delayed therapeutic hypothermia following cardiac arrest secondary to chloroquine toxicity
George Mark Haslam1, Matt C Thomas, Stephen R Laver
1Royal United Hospital, Anaesthesia, Royal United Hospital, Combe Park, Bath BA1 3NG, UK.
Abstract:
We describe a case of severe chloroquine intoxication resulting in a cardiac arrest requiring prolonged cardiopulmonary resuscitation. An excellent neurological outcome was achieved because the cardiac arrest occurred in a young patient lacking comorbidities in an environment where advanced life support was provided rapidly and effectively. Therapeutic hypothermia was instigated once profound shock and arrhythmias had resolved, and this may have contributed to her recovery. If a patient's immediate clinical condition post-cardiac arrest precludes therapeutic hypothermia, the use of this therapy should be reconsidered as their condition changes.
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