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Related Experiment Video

Updated: May 31, 2026

Non-restraining EEG Radiotelemetry: Epidural and Deep Intracerebral Stereotaxic EEG Electrode Placement

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Published on: June 25, 2016

Lamotrigine overdose associated with generalised seizures.

William Stephen Waring¹

¹The Royal Infirmary of Edinburgh, Scottish Poisons Information Bureau, Edinburgh, EH16 4SA, UK.

BMJ Case Reports

|June 21, 2011

Summary

Deliberate lamotrigine overdose can cause generalized seizures in susceptible individuals. Prompt treatment with intravenous benzodiazepines led to a full recovery in this case, highlighting the importance of monitoring lamotrigine levels.

Area of Science:

Neuroscience
Clinical Pharmacology

Background:

Lamotrigine is an anticonvulsant medication used to treat epilepsy and bipolar disorder.
Overdose of lamotrigine can lead to significant toxicity, including neurological adverse effects.
Generalized seizures are a known, albeit rare, potential complication of lamotrigine toxicity.

Purpose of the Study:

To report a case of generalized seizures induced by a deliberate lamotrigine overdose.
To highlight the clinical presentation, management, and outcome of lamotrigine toxicity.
To emphasize the importance of recognizing lamotrigine-induced seizures in overdose scenarios.

Main Methods:

Case report of a 42-year-old female patient presenting after intentional lamotrigine ingestion.
Clinical observation of seizure activity and response to treatment.

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Pharmacokinetic analysis including serum lamotrigine concentration and estimated elimination half-life.

Main Results:

The patient experienced generalized seizures following lamotrigine overdose.
Seizures were successfully terminated with intravenous benzodiazepine administration.
Peak serum lamotrigine concentration was 30 mg/l at 1.3 hours post-ingestion, significantly exceeding the therapeutic range.
The estimated elimination half-life of lamotrigine was prolonged at 18.3 hours.
The patient made a complete recovery without sequelae.

Conclusions:

Lamotrigine toxicity, particularly at high serum concentrations, can precipitate generalized seizures in susceptible individuals.
Prompt recognition and management with benzodiazepines are effective in controlling lamotrigine-induced seizures.
This case underscores the potential neurotoxicity of lamotrigine overdose and the need for vigilant monitoring.