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Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
10:28

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Published on: February 18, 2016

Multiple mononeuropathy following cocaine abuse.

Sándor Beniczky1, Peer Tfelt-Hansen, Martin Fabricius

  • 1Department of Clinical Neurophysiology, Danish Epilepsy Canter, Visbys Allé 5, 4293 Dianalund.

BMJ Case Reports
|June 21, 2011
PubMed
Summary

Cocaine use can cause nerve damage, leading to multiple mononeuropathy. Researchers suggest vasoconstriction from cocaine abuse may cause both muscle necrosis and this nerve condition.

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Area of Science:

  • Neurology
  • Toxicology
  • Neurophysiology

Background:

  • Cocaine abuse is linked to rhabdomyolysis, a muscle-damaging condition.
  • The mechanism causing neurological complications from cocaine abuse is not fully understood.

Purpose of the Study:

  • To investigate the neurophysiological findings in a patient with cocaine-induced rhabdomyolysis and acute neurological deficits.
  • To explore the potential link between cocaine-induced vasoconstriction and neuropathy.

Main Methods:

  • Case report of a 31-year-old male with acute left-sided weakness after cocaine inhalation.
  • Neurophysiological studies including nerve conduction studies and electromyography.
  • Assessment of rhabdomyolysis markers.

Main Results:

  • The patient presented with rhabdomyolysis and acute neurological deficits.
  • Neurophysiological studies revealed axonal degeneration in multiple sensory and motor nerves.
  • Conduction block, not typical of compression sites, was observed in several motor nerves, consistent with multiple mononeuropathy.

Conclusions:

  • The findings support a diagnosis of multiple mononeuropathy in this cocaine abuse case.
  • Vasoconstriction induced by cocaine is hypothesized to be the underlying cause of both rhabdomyolysis and the observed neuropathy.
  • This case highlights a potential neurological complication of cocaine use.