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Related Experiment Video

Updated: May 31, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

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Temporary allergy to Neocate: possible association with immunisation.

Douglas Ritchie Gillies¹, John Warner

¹Department of Paediatrics, Harrogate Hospital NHS Foundation Trust, Lancaster Park Road, Harrogate HG2 7SX, UK.

BMJ Case Reports

|June 21, 2011

Summary

An infant experienced allergic reactions to two different extensively hydrolyzed formulas, Nutramigen and Neocate, shortly after immunizations. However, the infant tolerated Neocate well upon reintroduction after a month, suggesting a potential transient sensitivity.

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Published on: June 24, 2020

Area of Science:

Pediatrics
Allergology
Immunology

Background:

Infant feeding allergies can be complex, particularly with specialized formulas.
The timing of allergic reactions in relation to medical interventions like immunizations warrants investigation.

Purpose of the Study:

To document a case of suspected allergic reactions to extensively hydrolyzed formulas in an infant.
To explore the potential role of recent immunizations in the onset of these reactions.
To assess the tolerance of specialized formulas after a period of avoidance.

Main Methods:

Case report of a 5-month-old infant.
Observation of adverse reactions following introduction of Nutramigen and Neocate.
Dietary reintroduction of Neocate after a one-month interval.

Main Results:

The infant showed allergic reactions to both Nutramigen and Neocate within days of their introduction.
No adverse effects were observed when Neocate was reintroduced one month later.

Conclusions:

The infant's reactions to extensively hydrolyzed formulas may have been transient or coincidental.
Further investigation is needed to understand the relationship between immunizations and formula intolerance in infants.
Successful reintroduction of Neocate suggests that the initial reactions were not indicative of a permanent intolerance.