Rickets and tracheobronchomalacia

Harish Bangalore1, Suniti Bisht, Baba Inusa

  • 1Evelina Children's Hospital, Paediatrics, St Thomas' Hospital, Westminster Bridge Road, London SE1 7EH, UK.

BMJ Case Reports
|June 21, 2011
PubMed

Insights

Rickets, a bone-weakening disease, is increasingly common. This case highlights severe respiratory issues in rickets, suggesting tracheobronchomalacia may be an under-recognized complication requiring further study.

Area of Science:

  • Pediatrics
  • Pulmonology
  • Endocrinology

Background:

  • Rickets incidence is rising globally, even in developed nations.
  • Respiratory infections are a known comorbidity of rickets.
  • Severe respiratory complications in rickets warrant investigation.

Purpose of the Study:

  • To report a case of rickets with significant respiratory compromise.
  • To identify potential underlying causes for respiratory distress in rickets.
  • To explore tracheobronchomalacia as a possible association with rickets.

Main Methods:

  • Case report presentation.
  • Clinical assessment of a child with rickets and respiratory symptoms.
  • Diagnostic bronchoscopy to evaluate airway abnormalities.

Main Results:

  • The patient presented with severe respiratory complications secondary to rickets.
  • Bronchoscopy revealed tracheobronchomalacia, a condition affecting the windpipe.
  • This finding suggests a potential link between rickets and airway instability.

Conclusions:

  • Tracheobronchomalacia may be an unrecognized complication of rickets.
  • Further research is needed to confirm and understand this association.
  • Early recognition and investigation of airway issues in rickets are crucial.

Related Concept Videos

Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
Trachea01:22

Trachea

The trachea, commonly known as the windpipe, is a vital part of the human respiratory system. It serves as a passageway for air to travel between the larynx and the bronchi, allowing oxygen to reach the lungs. Let's explore its anatomical features, dimensions, layers of the tracheal wall, associated muscles, and the functions of its parts.
Anatomical Features:
Location: About half of the trachea is situated in the neck, anterior to the esophagus, and extends from the larynx (at the level of the...
Breathing01:05

Breathing

The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
The Bronchial Tree01:23

The Bronchial Tree

The human bronchi and bronchial tree play a crucial role in the respiratory system, facilitating the exchange of oxygen and carbon dioxide. Let's delve into the intricate structure and functions of these respiratory components.
The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...