Related Experiment Video
Updated: May 31, 2026

Validation of Therapeutic Agent Conjugation to Polyvinyl Alcohol-Coated Medical Devices
Published on: November 29, 2024
Prolonged gastric stasis of enteric-coated granules
Yoshihiro Matsukawa1, Izumi Hayashi
1Nihon University School of Medicine, Department of Medicine, Division of Hematology and Rheumatology, Oyaguchi-Kamimachi Itabashi, Tokyo, Japan.
Abstract:
A 90-year-old woman with reflux oesophagitis had been receiving a regimen of a generic brand of lansoprazole (15 mg/day), an aspirin tablet (81 mg), and anti-hypertensive medicines. In 2008 she underwent a gastroduodenoscopic examination more than 3 hours after ingesting these medicines. The endoscopy revealed white substances in the antrum and an oval-shaped agglomeration of granules in the stomach body. No specific findings such as pylorus stenosis were confirmed. Because the lansoprazole capsule was designed to dissolve in the intestine, the therapeutic concentration could not be obtained in the blood until 3 hours after the ingestion. When prescribing medication for elderly people with gastrointestinal hypomotility, physicians should note the bioavailability of the drugs, especially when using delayed-release capsules with enteric-coated granules inside.
Related Concept Videos
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Pyloric Obstruction
Gastritis II: Pathophysiology
Gastric Emptying
Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Oral Drug Delivery Systems: Delayed-Release Systems
