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Updated: May 31, 2026

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

Published on: September 3, 2020

Myocardial infarction and stem cells.

K Ananda Krishna¹, K Sai Krishna, Ruben Berrocal

¹Department of Biotechnology, Acharya Nagarjuna University, Guntur - 522 510, India.

Journal of Pharmacy & Bioallied Sciences

|June 21, 2011

Summary

Stem cell therapy offers a promising approach for cardiac repair after myocardial infarction (MI) by regenerating damaged heart tissue. Further research is needed to confirm its benefits for improving heart function post-MI.

Keywords:

Cardiomyocytes myocardial infarction stem cell transplantation stem cells

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Intramyocardial Cell Delivery: Observations in Murine Hearts

Intramyocardial Cell Delivery: Observations in Murine Hearts

Published on: January 24, 2014

Area of Science:

Cardiology
Regenerative Medicine
Stem Cell Biology

Background:

Myocardial infarction (MI) causes irreversible cardiomyocyte loss and scar formation, impairing cardiac function.
Current therapies manage mortality and secondary events but do not replace damaged cardiac cells.
There is a critical need for treatments that promote cardiac tissue regeneration and restore heart function post-MI.

Purpose of the Study:

To review the clinical applications of stem cells in cardiac repair following myocardial infarction.
To explore the potential of stem cell-based therapies for myocardial regeneration.
To address the current understanding of stem cell benefits for improving cardiac function.

Main Methods:

Literature review focusing on clinical studies and research concerning stem cell therapy for cardiac repair.
Analysis of existing data on stem cell applications in treating myocardial infarction.
Synthesis of current knowledge on myocardial regeneration strategies using stem cells.

Main Results:

Stem cell application is a growing area of interest for myocardial regeneration.
Potential benefits of stem cell therapy for cardiac repair require further investigation.
Clinical applications of stem cells in cardiac repair are being actively explored.

Conclusions:

Stem cell therapy presents a potential therapeutic option for replacing damaged cardiomyocytes after MI.
Further clinical validation is essential to establish the efficacy of stem cell-based treatments for cardiac function improvement.
This review consolidates current knowledge on stem cells for cardiac repair, highlighting areas for future research.