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Updated: May 31, 2026

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
Published on: May 21, 2018
Role of the nlrp3 inflammasome in microbial infection
Paras K Anand1, R K Subbarao Malireddi, Thirumala-Devi Kanneganti
1Department of Immunology, St Jude Children's Research Hospital Memphis, TN, USA.
Abstract:
The intracellular Nod-like receptor Nlrp3 has emerged as the most versatile innate immune receptor because of its broad specificity in mediating immune response to a wide range of microbial or danger signals. Nlrp3 mediates assembly of the inflammasome complex in the presence of microbial components leading to the activation of caspase-1 and the processing and release of the pro-inflammatory cytokines IL-1β and IL-18. In this review, we give an update on the recent literature examining the role of Nlrp3 inflammasome in response to fungal, bacterial, and viral infections.
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