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Lysis from without.

Stephen T Abedon1

  • 1Department of Microbiology; The Ohio State University; Mansfield, OH USA.

Bacteriophage
|June 21, 2011
PubMed
Summary
This summary is machine-generated.

Lysis from without (LO) describes bacterial death from phage interactions, either via virion adsorption (LO(V)) or lysin application (LO(L)). Further research is needed to confirm LO(V) potential before its application in phage therapy.

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Area of Science:

  • Microbiology
  • Bacteriology
  • Virology

Background:

  • The term "lysis from without" (LO) describes bacterial lysis caused by bacteriophages.
  • LO can occur through high virion adsorption (LO(V)) or exogenous lysin application (LO(L)).

Purpose of the Study:

  • To examine the biological relevance and applications of "lysis from without" (LO).
  • To clarify the distinction between LO(V) and other phage-induced bacterial killing mechanisms.

Main Methods:

  • Review of existing literature on LO, phage-bacterial interactions, and phage therapy.
  • Analysis of mechanistic studies on LO(V) for T4 phages and related phenomena.

Main Results:

  • LO(V) is a distinct phenomenon from general bacterial killing by high phage multiplicities.
  • LO(V) has been mechanistically studied, linked to phage eclipse, and has implications for phage ecology and therapy.
  • Resistance to LO (LO(R)) is mediated by specific phage gene products.

Conclusions:

  • The term "abortive infection" may serve as a broader descriptor for non-productive phage infections that result in bacterial death.
  • Experimental in vitro confirmation is crucial before applying the LO(V) designation, given that not all phages induce this effect.