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Plague

Plague

Plague is a highly virulent zoonotic disease caused by Yersinia pestis, a Gram-negative, facultatively anaerobic coccobacillus. This pathogen primarily circulates among rodent populations and is transmitted to humans through the bite of infected fleas. Additional transmission routes include direct contact with infected animal tissue or inhalation of respiratory droplets from individuals with pneumonic plague. These multiple transmission pathways highlight the bacterium’s potential for rapid...

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Related Experiment Video

Updated: May 31, 2026

An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei

An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei

Published on: February 17, 2014

Model systems to study plague pathogenesis and develop new therapeutics.

Matthew B Lawrenz¹

¹Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, Department of Microbiology and Immunology, University of Louisville School of Medicine Louisville, KY, USA.

Frontiers in Microbiology

|June 21, 2011

Summary

This summary is machine-generated.

Yersinia pestis causes plague through various infection routes. Research is ongoing to understand its pathogenesis and develop new therapeutics using established in vivo models.

Keywords:

Yersinia pestis animal models plague vaccines

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Area of Science:

Microbiology
Infectious Diseases
Bacteriology

Background:

Yersinia pestis is a Gram-negative bacterium responsible for plague in humans.
Plague has caused three major pandemics and has historical biowarfare implications.
The potential for plague as a bioweapon necessitates research into Y. pestis pathogenesis and therapeutics.

Purpose of the Study:

To review in vivo models used for Yersinia pestis research.
To highlight the importance of understanding Y. pestis pathogenesis.
To inform the development of novel plague therapeutics.

Main Methods:

Review of existing literature on Yersinia pestis in vivo models.
Analysis of different routes of Y. pestis infection.
Examination of research strategies for plague therapeutics.

Main Results:

Multiple in vivo models exist for studying Yersinia pestis.
These models facilitate research into bacterial pathogenesis.
The models support the development of new treatment strategies.

Conclusions:

In vivo models are crucial for advancing plague research.
Understanding Y. pestis infection routes is key to control.
Continued research is vital for combating plague threats.