[Dynamics of changes in rat osseous system in chronic cadmium poisoning]

The rats were given subcutaneously CdSO4 in doses 0.7 mg/kg of body weight once a week during one year. After the lapse of 6, 9 and 12 months, the animals were sacrificed and their blood was used to determine the preselected biochemical indices (erythrocytes, hemoglobin, hematocrit, levels of protein, albumins, globulins GOT, GPT, AP and its isoenzymes, calcium, inorganic phosphorus, urea and creatinines). Simultaneously radiological examinations were performed on prepared and dehydrated long bones being estimated. Changes were revealed in morphological parameters of long bones with a marked demineralisation of epiphyses after 9 months of investigations. The above changes were found to correlate with those referring to biochemical indices levels, intensifying with the increase of the exposure period.