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[Significance of decreasing high density lipoproteins in cerebrovascular diseases]
Insights
Low levels of high-density lipoprotein cholesterol (HDL-C) are linked to cerebrovascular diseases (CVD). This reduction occurs early, even before stroke, and is more pronounced than in coronary heart disease.
Area of Science:
- Biochemistry
- Neurology
- Cardiovascular Medicine
Context:
- Previous research indicated a decrease in serum high-density lipoprotein cholesterol (HDL-C) in cerebrovascular diseases (CVD).
- This study investigates lipoprotein patterns in 425 CVD patients, including those hospitalized for apoplexy and those with milder conditions or under normal living conditions.
Purpose:
- To further investigate the reduction of HDL levels in various cerebrovascular disease cases.
- To determine if HDL lowering is an early risk factor for CVD, preceding apoplexy.
- To compare the degree of HDL lowering in CVD with that observed in coronary heart disease (CHD).
Summary:
- A significant reduction in HDL levels (including HDL-C and apolipoprotein A1) was observed in 425 CVD patients.
- This reduction was evident in patients hospitalized for stroke (cerebral infarction or hemorrhage) and those with cerebrovascular insufficiency, transient ischemic attacks, or residual symptoms.
- HDL lowering in CVD patients was more pronounced than in CHD patients, where elevated apoB and total cholesterol were prominent; CVD groups showed normal or lower apoB and total cholesterol.
Impact:
- Suggests that HDL lowering is an early risk factor for cerebrovascular diseases, potentially preceding apoplectic events.
- Highlights distinct lipoprotein pattern differences between cerebrovascular diseases and coronary heart disease.
- Provides further evidence for the role of lipid metabolism in the pathogenesis of cerebrovascular diseases.
Abstract:
Significant decrease of serum high density lipoprotein cholesterol (HDL-C) in cerebrovascular diseases (CVD) was mentioned in our previous report (1981). The results of further studies on lipoprotein patterns of 425 cases of various CVD are presented. Reduction of HDL level (including both HDL-C and apolipoprotein A1) was observed not only in the group of patients hospitalized due to apoplexy (cerebral infarction or hemorrhage), but also in patients under normal living conditions. The latter group included patients with cerebrovascular insufficiency, transient ischemic attacks mild residual neuro-muscular symptoms after recovery from stroke. It is surmised that HDL lowering was present early in CVD cases before attack of apoplexy and is one of the risk factors of CVD The degree of HDL lowering in CVD groups were much more marked than that in our reported cases of coronary heart disease (CHD). The prominent change of lipoprotein pattern in CHD group was elevation of apoB and total cholesterol (TC); however, apoB and TC were approximately normal or significantly lower in certain CVD groups.