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Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
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Autoimmune Disorders

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Concept and Mechanism of Autoimmune Diseases
The immune system...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

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Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

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Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

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[Management of systemic lupus erythematosus-Including secondary antiphospholipid syndrome, fertility and pregnancy : S3 guidelines of the German Society for Rheumatology and Clinical Immunology and the German Society for Neurology (DGN), German Society for Internal Medicine (DGIM), German Cardiac Society (DGK), Society for Thrombosis and Hemostasis Research (GTH), German Society for Hematology and Medical Oncology (DGHO), German Society for Pediatric and Adolescent Medicine (DGKJ), Society for Pediatric and Adolescent Rheumatology (GKJR), German Society for Nephrology (DGfN), German Society for Pneumology and Ventilation Medicine (DGP), German Rheumatism League National Association, Lupus Erythematosus Self-help Community, German Dermatological Society (DDG). Version: 1.2].

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Refractory mixed proliferative and membranous lupus nephritis treated with the topoisomerase I inhibitor irinotecan as add-on therapy.

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Related Experiment Video

Updated: May 31, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

[Systemic lupus erythematosus].

M Aringer1, F Hiepe

  • 1Medizinische Klinik und Poliklinik III, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland. martin.aringer@uniklinikum-dresden.de

Zeitschrift Fur Rheumatologie
|June 21, 2011
PubMed
Summary
This summary is machine-generated.

Systemic lupus erythematosus (SLE) is a complex autoimmune disease primarily affecting women. While treatments have improved outcomes, managing SLE patients requires addressing ongoing risks like infections and cardiovascular issues.

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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Area of Science:

  • Autoimmune diseases
  • Rheumatology
  • Immunology

Context:

  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder.
  • Affects women of childbearing age predominantly, with a prevalence below 1:1,000.
  • Historically, severe SLE was fatal, but advancements have improved prognosis.

Purpose:

  • To present the current management strategies for SLE patients.
  • To review the state-of-the-art in handling this systemic autoimmune disease.

Summary:

  • SLE management has evolved with corticosteroids, cyclophosphamide, and novel therapies.
  • While direct SLE-related mortality is now uncommon, complications like infections, thromboses, and accelerated atherosclerosis remain significant concerns.
  • The review focuses on contemporary approaches to SLE patient care.

Impact:

  • Improved survival rates for SLE patients.
  • Highlights the need for continued vigilance regarding SLE complications.
  • Provides a comprehensive overview for clinicians managing SLE.