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Updated: May 31, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
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The association between the PTPN22 C1858T polymorphism and systemic sclerosis: a meta-analysis

Young Ho Lee1, Sung Jae Choi, Jong Dae Ji

  • 1Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1 Anam-dong 5-ga, Seongbuk-gu, Seoul 136-705, Korea. lyhcgh@korea.ac.kr

Molecular Biology Reports
|June 21, 2011
PubMed
Summary

The PTPN22 C1858T gene variant increases systemic sclerosis (SSc) risk, particularly in Europeans. This polymorphism is linked to anti-centromere antibody-positive SSc but not anti-topoisomerase antibody-positive SSc.

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