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Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome
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[Correlation between essential hypertension and carotid intima media thickness in children]

Bianca Popovici1, O Brumaru

  • 1Universitatea "Transilvania" Braşov, Facultatea de Medicină, Universitaţii de Medicină si Farmacie "Gr.T. Popa" laşi.

Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi
|June 22, 2011
PubMed

Insights

Essential hypertension is increasingly diagnosed in children. This study found increased carotid intima-media thickness in hypertensive children, strongly correlating with blood pressure and obesity, suggesting early endothelial dysfunction.

Area of Science:

  • Pediatric Cardiology
  • Vascular Biology
  • Hypertension Research

Background:

  • Essential hypertension is a growing concern in pediatric populations.
  • Early detection of cardiovascular changes in children with hypertension is crucial.

Purpose of the Study:

  • To investigate whether carotid intima-media thickness (CIMT) is elevated in children diagnosed with essential hypertension.
  • To explore the relationship between CIMT, blood pressure, body mass index (BMI), and left ventricular mass index (LVMI) in this cohort.

Main Methods:

  • A case-control study comparing 78 children with essential hypertension to 53 healthy controls.
  • Measurements included carotid intima-media thickness, left ventricular mass index, and body mass index.
  • Statistical analysis assessed correlations between CIMT and clinical parameters.

Main Results:

  • Elevated CIMT was observed in 65.38% of hypertensive children compared to controls.
  • Hypertensive children showed higher rates of obesity (82.05%) and increased LVMI (51.28%).
  • CIMT significantly correlated with systolic blood pressure, diastolic blood pressure, and BMI (P < 0.00001).

Conclusions:

  • Increased CIMT is prevalent in children with essential hypertension.
  • The strong association between hypertension and obesity in children complicates attributing CIMT solely to hypertension.
  • CIMT evaluation may serve as an indicator of early endothelial dysfunction in pediatric hypertension.
Abstract

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