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One-step Negative Chromatographic Purification of Helicobacter pylori Neutrophil-activating Protein Overexpressed in Escherichia coli in Batch Mode
Published on: June 18, 2016
[Proton pump inhibitor H2 receptor antagonist]
Akiko Shiotani1, Tomoari Kamada, Hiroaki Kusunoki
1Department of Internal Medicine, Kawasaki Medical School.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|June 22, 2011
Summary
Proton pump inhibitors (PPIs) are most effective for preventing and treating NSAID-related peptic ulcers, especially in high-risk patients. While H2 receptor antagonists (H2RAs) show efficacy, PPIs offer a superior safety and effectiveness profile.
Area of Science:
- Gastroenterology
- Pharmacology
Context:
- Recent establishment of Japanese guidelines for peptic ulcer treatment.
- Focus on NSAID-associated peptic ulcers, including low-dose aspirin.
- Evaluation of proton pump inhibitors (PPIs) and H2 receptor antagonists (H2RAs).
Purpose:
- To review the efficacy and safety of PPIs and H2RAs for peptic ulcer prophylaxis and treatment in the context of NSAID use.
- To compare PPIs with H2RAs and misoprostol for managing NSAID-induced ulcers.
Summary:
- Double-dose H2RAs are effective for preventing NSAID-related ulcers but not superior to PPIs.
- Full-dose misoprostol and PPIs show comparable clinical efficacy, but misoprostol has compliance issues due to adverse effects.
- PPIs demonstrate the best efficacy and side-effect profile for healing and preventing NSAID-associated ulcers, particularly in high-risk individuals.
Impact:
- Provides evidence-based recommendations for selecting pharmacotherapy for NSAID-induced peptic ulcers.
- Highlights the advantages of PPIs for high-risk patients requiring NSAID therapy.
- Informs clinical practice and guideline development for peptic ulcer management.
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