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Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
[Pathogenic mechanism of NSAIDs-induced mucosal injury in lower gastrointestinal tract]
Kazuko Beppu1, Taro Osada, Tomoyoshi Shibuya
1Department of Gastroenterology, Juntendo University School of Medicine.
Abstract:
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for musculoskeletal pain and inflammation. Because low-dose aspirins reduce the risk of coronary and cerebrovascular events, consumption of them are rising worldwide. However, NSAIDs induce ulcers and bleeding not only in upper gastrointestinal tract but also in the small and large intestine. The recent advanced modalities such as double balloon endoscopy and video-capsule endoscopy enable the detection of NSAIDs-induced mucosal injury in the small intestine accurately. Topical direct injury of NSAIDs and cyclooxygenase (COX) inhabitation resulting in prostaglandin (PG) suppression are two main pathogenic mechanisms of lower gastrointestinal damage. Further analysis for the mechanism of effect and side effect of NSAIDs are warranted to develop the therapeutic and prevention method of NSAIDs-induced lower gastrointestinal mucosal injury.
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