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Related Concept Videos

Ion-Exchange Chromatography01:09

Ion-Exchange Chromatography

Ion-exchange chromatography, or IEC, is a technique for separating ions based on their affinity for the stationary phase. The stationary phase is a cross-linked polymer resin with covalently attached ionic functional groups. The functional groups can be either positively charged (cation exchangers) or negatively charged (anion exchangers). A cation exchanger consists of a polymeric anion and active cations, while an anion exchanger is a polymeric cation with active anions. The choice of...
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Gas Chromatography: Types of Columns and Stationary Phases

Gas chromatography (GC) relies on stationary phases to separate and analyze components in a sample. There are two main types of stationary phases: liquid and solid. Liquid stationary phases are non-volatile, thermally stable, and chemically inert liquids coated onto the column. Solid stationary phases are particles of adsorbent material, such as silica gel or molecular sieves.
For an analyte to remain on the column for a sufficient amount of time, it must exhibit some level of compatibility (or...
Ion Exchange01:17

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Ion exchange chromatography separates charged molecules from a solution by reversibly exchanging them with mobile, or 'active', ions associated with the oppositely charged stationary phase. This method can be used to separate ions, soften and deionize water, and purify solutions. The polymers comprising the ion-exchange column are high-molecular-weight and chemically stable polymers, crosslinked to be porous and essentially insoluble. They are also functionalized with either acidic or basic...
High-Performance Liquid Chromatography: Introduction01:11

High-Performance Liquid Chromatography: Introduction

High-performance liquid chromatography(HPLC), formerly referred to as High-pressure liquid chromatography, is a powerful technique used to separate, identify, and quantify components in complex mixtures. The term "high pressure" refers to using high pressure to push the liquid mobile phase through the tightly packed columns.
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Chromatographic Methods: Classification01:12

Chromatographic Methods: Classification

Chromatographic techniques are classified in three ways: the classification is based on the physical state of the stationary and mobile phases, how the mobile phase and the stationary phase contact each other, or through the chemical or physical processes that isolate the components of the sample. Typically, the mobile phase is either a liquid or gas, while the stationary phase is either a solid or a liquid layer applied to a solid surface.
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Chromatography: Introduction01:10

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Chromatography is a technique used to separate compounds based on differences of partitioning between two phases, the stationary phase and the mobile phase.
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Monolithic phases for ion chromatography.

Anna Nordborg1, Emily F Hilder, Paul R Haddad

  • 1Australian Center for Research on Separation Science, School of Chemistry, University of Tasmania, Hobart, Tasmania 7001, Australia. Paul.Haddad@utas.edu.au

Annual Review of Analytical Chemistry (Palo Alto, Calif.)
|June 22, 2011
PubMed
Summary
This summary is machine-generated.

Monolithic media are emerging as a popular alternative to traditional packed columns in ion chromatography (IC). This review covers synthesis, characterization, and applications of polymeric and silica monoliths for routine IC use.

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Area of Science:

  • Analytical Chemistry
  • Separation Science
  • Materials Science

Background:

  • Monolithic media are gaining popularity in chromatographic applications.
  • Commercially available monolithic materials offer a viable alternative to packed-bed columns for routine ion chromatography (IC).

Purpose of the Study:

  • To discuss strategies for synthesizing polymeric and silica monoliths with ion-exchange functionality.
  • To review materials characterization techniques, focusing on nondestructive methods for surface functionality analysis.
  • To present selected IC applications of monolithic media from 2008-2010.

Main Methods:

  • Synthesis of polymeric and silica monoliths via direct incorporation or post-polymerization modification (grafting, coating) of ion-exchange groups.
  • Characterization of monolith surface functionality using nondestructive techniques, including in situ analysis.
  • Review of published ion chromatography applications utilizing monolithic stationary phases.

Main Results:

  • Various strategies exist for preparing ion-exchange monoliths suitable for IC.
  • Nondestructive characterization methods are crucial for analyzing monolith surface properties.
  • Monolithic media have demonstrated utility in diverse IC applications.

Conclusions:

  • Monolithic media represent a practical and increasingly popular choice for routine ion chromatography.
  • Effective synthesis and characterization are key to optimizing monolithic materials for IC.
  • The reviewed applications highlight the growing impact of monoliths in ion chromatography.