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Updated: May 31, 2026

Preparation of Adipose Progenitor Cells from Mouse Epididymal Adipose Tissues
Published on: August 25, 2020
Adipocytes as a new source of catecholamine production
Peter Vargovic1, Jozef Ukropec, Marcela Laukova
1Laboratory of Stress Research, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia. peter.vargovic@gmail.com
Abstract:
Catecholamines are an important regulator of lipolysis in adipose tissue. Here we show that rat adipocytes, isolated from mesenteric adipose tissue, express genes of catecholamine biosynthetic enzymes and produce catecholamines de novo. Administration of tyrosine hydroxylase inhibitor, alpha-methyl-p-tyrosine, in vitro significantly reduced concentration of catecholamines in isolated adipocytes. We hypothesize that the sympathetic innervation of adipose tissues is not the only source of catecholamines, since adipocytes also have the capacity to produce both norepinephrine and epinephrine.
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