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Updated: Aug 11, 2026

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
09:43

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

Published on: March 30, 2018

[Subclinical course of Epstein-Barr virus infection in infants with transient hepatitis]

A Pohl-Koppe1, M Gabriel

  • 1Institut für Virologie und Immunbiologie, Universität Würzburg.

Monatsschrift Kinderheilkunde : Organ Der Deutschen Gesellschaft Fur Kinderheilkunde
|July 1, 1990
PubMed

Insights

Primary Epstein-Barr Virus (EBV) infection in infants can cause mild symptoms. This case highlights a rare instance where EBV infection in infancy presented as transient hepatitis with elevated liver enzymes.

Area of Science:

  • Pediatric Infectious Diseases
  • Hepatology
  • Virology

Background:

  • Epstein-Barr Virus (EBV) is a common human herpesvirus.
  • Primary EBV infections typically manifest as infectious mononucleosis in adolescents and young adults.
  • In infants and young children, EBV infections are often asymptomatic or present with mild, non-specific symptoms.

Observation:

  • A case of primary EBV infection in an infant is presented.
  • The infant experienced clinically inapparent infection initially.
  • Pathological elevation of liver enzymes was observed, indicating liver involvement.

Findings:

  • The infant's primary EBV infection resulted in transient hepatitis.
  • Elevated liver enzymes were the key indicator of hepatic involvement.
  • This presentation is atypical for EBV in early childhood.

Implications:

  • This case expands the spectrum of clinical presentations for primary EBV infection in infancy.
  • It underscores the importance of considering EBV in the differential diagnosis of hepatitis in infants.
  • Further research may elucidate the mechanisms behind EBV-associated hepatitis in this age group.

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