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Opportunistic infection-associated immune reconstitution syndrome in transplant recipients

Hsin-Yun Sun1, Nina Singh

  • 1Infectious Diseases Section, VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania 15240, USA.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|June 22, 2011
PubMed

Reversal of pathogen-induced immunosuppression upon employment of effective antimicrobial therapy and withdrawal of iatrogenic immunosuppression has the potential to shift the host immune repertoire towards pathologic inflammatory responses conducive to immune reconstitution syndrome (IRS). Posttransplant IRS has been observed with fungi, M. tuberculosis, cytomegalovirus, and polyoma virus nephropathy. This review discusses the existing state of knowledge regarding IRS and the immune mechanisms that underlie its pathogenesis, with significant implications for developing reliable diagnostic biomarkers and optimal management strategies for post-transplant opportunistic infection-associated IRS.

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