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Updated: Sep 16, 2026

Transcriptional Analysis by Nascent RNA FISH of In Vivo Trophoblast Giant Cells or In Vitro Short-term Cultures of Ectoplacental Cone Explants
Published on: August 31, 2016
Gestational trophoblastic neoplasia
1Johns Hopkins Hospital, Baltimore, MD 21205.
Abstract:
Gestational trophoblastic neoplasia (GTN) constitutes a spectrum of benign and malignant diseases that are associated with conception. The majority of patients with a benign GTN (hydatidiform mole) spontaneously enter remission after evacuation; however, 15% to 20% will develop a malignant form of GTN. The malignant GTN are classified as nonmetastatic GTN and metastatic GTN. Chemotherapy is the mainstay of treatment for malignant GTN. Patients require continuous emotional support during intense medical therapy because of issues related to the treatment and future pregnancies.
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