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Updated: May 31, 2026

Characterizing the Composition of Molecular Motors on Moving Axonal Cargo Using "Cargo Mapping" Analysis
Published on: October 30, 2014
Sequence heterogeneity and the dynamics of molecular motors
1Physicochimie Curie (CNRS-UMR168), Institut Curie, Section de Recherche, 26 rue d'Ulm, 75248 Paris Cedex 05, France.
Abstract:
The effect of sequence heterogeneity on the dynamics of molecular motors is reviewed and analysed using a set of recently introduced lattice models. First, we review results for the influence of heterogeneous tracks such as a single strand of DNA or RNA on the dynamics of the motors. We stress how the predicted behaviour might be observed experimentally in anomalous drift and diffusion of motors over a wide range of parameters near the stall force and discuss the extreme limit of strongly biased motors with one-way hopping. We then consider the dynamics in an environment containing a variety of different fuels which supply chemical energy for the motor motion, either on a heterogeneous or on a periodic track. The results for motion along a periodic track are relevant to kinesin motors in a solution with a mixture of different nucleotide triphosphate fuel sources.
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