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Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
Published on: June 6, 2025
Managing kidney disease with blood-pressure control
1Division of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, University of Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany.
Nature Reviews. Nephrology
|June 22, 2011
Summary
Hypertension accelerates chronic kidney disease (CKD) progression. Pharmacological interventions, particularly renin-angiotensin system blockade with ACE inhibitors or ARBs, effectively lower blood pressure and proteinuria, offering significant nephroprotection.
Area of Science:
- Nephrology
- Cardiovascular Medicine
Background:
- Chronic kidney disease (CKD) progression is often independent of the initial cause once renal function declines.
- Hypertension is a significant risk factor for CKD progression in both pediatric and adult populations.
Purpose of the Study:
- To review the role of hypertension in CKD progression.
- To discuss antihypertensive agents as a therapeutic strategy for preventing CKD progression.
Main Methods:
- Review of clinical trial evidence on pharmacological interventions for CKD progression.
- Analysis of the impact of renin-angiotensin system blockade on blood pressure and proteinuria.
Main Results:
- Pharmacological interventions can significantly slow CKD progression.
- Angiotensin-converting-enzyme inhibitors and angiotensin-receptor blockers offer effective blood pressure and proteinuria control, leading to improved nephroprotection.
- Tight blood pressure control to low-normal ranges may provide additional benefits, especially in younger patients and those with proteinuria.
Conclusions:
- Hypertension management is crucial for slowing CKD progression.
- Renin-angiotensin system inhibitors are key agents for nephroprotection in CKD.
- Targeting blood pressure and proteinuria with specific antihypertensive strategies is essential for long-term kidney health.
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