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Updated: May 31, 2026

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection
Published on: July 21, 2013
Vertebrobasilar artery occlusion
Jessica C Schoen1, Megan M Boysen, Chase R Warren
1University of California, Irvine School of Medicine, Irvine, CA.
Insights
Vertebrobasilar artery occlusion diagnosis is often delayed due to varied symptoms and imaging challenges. Prompt recanalization of the occluded vessel is key to improving patient outcomes and reducing mortality.
Area of Science:
- Neurology
- Vascular Neurology
- Neuroimaging
Background:
- Vertebrobasilar artery occlusion presents variably, often delaying diagnosis.
- Posterior circulation territories are challenging to visualize, typically requiring advanced imaging.
- Delayed diagnosis impacts treatment initiation and patient prognosis.
Purpose of the Study:
- To review the literature on vertebrobasilar artery occlusion.
- To present a case study of a patient with altered mental status due to this condition.
- To highlight diagnostic and treatment considerations.
Main Methods:
- Literature review of vertebrobasilar artery occlusion.
- Case report of a patient with altered mental status.
- Discussion of diagnostic imaging (angiography, MRI) and treatment (thrombolysis).
Main Results:
- Recanalization of the occluded artery significantly improves outcomes.
- Altered mental status can be a presenting symptom.
- Timely diagnosis and intervention are crucial.
Conclusions:
- Vertebrobasilar artery occlusion requires a high index of suspicion.
- Advanced imaging is essential for diagnosis.
- Vessel recanalization is a critical therapeutic goal.
Abstract:
The presentation of vertebrobasilar artery occlusion varies with the cause of occlusion and location of ischemia. This often results in delay in diagnosis. Areas of the brain supplied by the posterior circulation are difficult to visualize and usually require angiography or magnetic resonance imaging. Intravenous thrombolysis and local-intra arterial thrombolysis are the most common treatment approaches used. Recanalization of the occluded vessel significantly improves morbidity and mortality. Here we present a review of the literature and a case of a patient with altered mental status caused by vertebrobasilar artery occlusion.
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