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Related Concept Videos

Pain01:20

Pain

Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
Sympathetic Activation01:16

Sympathetic Activation

The sympathetic division can influence tissues and organs by releasing norepinephrine at peripheral synapses and distributing epinephrine and norepinephrine through the bloodstream. In times of crisis or stress, sympathetic activation occurs, which is regulated by sympathetic centers in the hypothalamus. As a result, sympathetic activation prepares the body for physical exertion, rapid ATP production, and heightened alertness, allowing individuals to respond effectively to challenging or...

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Related Experiment Video

Updated: May 31, 2026

Psychophysically-anchored, Robust Thresholding in Studying Pain-related Lateralization of Oscillatory Prestimulus Activity
07:28

Psychophysically-anchored, Robust Thresholding in Studying Pain-related Lateralization of Oscillatory Prestimulus Activity

Published on: January 21, 2017

[Pain words activate pain-processing neural structures].

M Richter1, W Miltner, T Weiss

  • 1Institut für Psychologie, Lehrstuhl für Klinische und Biologische Psychologie, Am Steiger 3/1, 07743 Jena, Deutschland. Maria.Richter@med.uni-jena.de

Schmerz (Berlin, Germany)
|June 22, 2011
PubMed
Summary
This summary is machine-generated.

Processing pain words activates specific brain regions, not just general negative emotions. Attention significantly modulates these pain-specific neural responses.

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Related Experiment Videos

Last Updated: May 31, 2026

Psychophysically-anchored, Robust Thresholding in Studying Pain-related Lateralization of Oscillatory Prestimulus Activity
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Quantifying Pain Location and Intensity with Multimodal Pain Body Diagrams
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Quantifying Pain Location and Intensity with Multimodal Pain Body Diagrams

Published on: July 7, 2023

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Pain Research

Context:

  • Previous research indicates the neural
  • pain matrix
  • activates with pain cues.
  • Uncertainty exists whether this activation is specific to pain or general negative affect/arousal.

Purpose:

  • Investigate neural mechanisms of processing pain-related words versus negative, positive, and neutral words.
  • Determine if brain activation is specific to pain content or valence/arousal.
  • Examine the influence of attentional demands on pain word processing.

Summary:

  • During an imagination task, pain words increased activation in dorsolateral prefrontal cortex (DLPFC) and inferior parietal cortex (IPC).
  • In a distraction task, pain words decreased dorsal anterior cingulate cortex (dACC) activation and increased subgenual anterior cingulate cortex (sACC) activation.
  • These findings demonstrate content-specific processing of pain words, modulated by attention, not just valence or arousal.

Impact:

  • Provides evidence for content-specific neural processing of pain-related stimuli.
  • Highlights the role of attention in modulating pain-related brain activity.
  • Clarifies the neural basis of pain word processing, distinguishing it from general emotional responses.