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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...
Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
Drugs in...
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...

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Related Experiment Video

Updated: May 31, 2026

Delivery of Antibodies into the Murine Brain via Convection-enhanced Delivery
08:22

Delivery of Antibodies into the Murine Brain via Convection-enhanced Delivery

Published on: July 18, 2019

Drug delivery embolization systems: a physician's perspective.

Antonio Nicolini1, Silvia Crespi, Laura Martinetti

  • 1IRCCS-Fondazione Ca' Granda Ospedale Maggiore Policlinico Milano, Interventional radiology, Via Francesco Sforza 35, Milano 20100, Italy. anicolini@policlinico.mi.it

Expert Opinion on Drug Delivery
|June 23, 2011
PubMed
Summary
This summary is machine-generated.

Transarterial chemoembolization (TACE) is effective for liver tumors, especially hepatocellular carcinoma (HCC). Drug-eluting beads may enhance TACE outcomes for HCC and colorectal liver metastases, improving patient survival.

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Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization
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Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization

Published on: December 2, 2013

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Delivery of Antibodies into the Murine Brain via Convection-enhanced Delivery
08:22

Delivery of Antibodies into the Murine Brain via Convection-enhanced Delivery

Published on: July 18, 2019

Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization
09:49

Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization

Published on: December 2, 2013

Area of Science:

  • Hepatology
  • Interventional Radiology
  • Oncology

Background:

  • Increasing global incidence of primary and secondary liver cancers necessitates advanced treatment strategies.
  • Multidisciplinary approaches and individualized patient care are crucial for managing complex liver tumoral diseases.
  • Understanding treatment pros and cons is vital for informed decision-making in liver cancer therapy.

Purpose of the Study:

  • To review the epidemiology of liver cancers.
  • To elucidate the principles, benefits, and applications of conventional transarterial chemoembolization (TACE).
  • To explore the potential of novel TACE technologies, such as drug-eluting beads.

Main Methods:

  • Literature review of primary and secondary liver cancers.
  • Analysis of conventional transarterial chemoembolization (TACE) efficacy and limitations.
  • Evaluation of drug-eluting beads as an advancement in TACE therapy.

Main Results:

  • Transarterial chemoembolization (TACE) has proven efficacy in improving survival for hepatocellular carcinoma (HCC).
  • Conventional TACE has limitations that newer methods aim to address.
  • Drug-eluting beads show promise in overcoming limitations of traditional TACE.

Conclusions:

  • Management of focal liver lesions requires collaboration among specialists, including interventional radiologists.
  • Drug-eluting microspheres appear to enhance TACE effectiveness for both HCC and colorectal liver metastases.
  • Optimized TACE strategies, potentially using drug-eluting technologies, are key to improving outcomes for liver cancer patients.