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Published on: November 20, 2015
Placental abruption and premature rupture of membranes
Vibecke Høgberg Markhus1, Svein Rasmussen, Stein Atle Lie
1Institute of Clinical Medicine, University of Bergen, Bergen, Norway.
Objective:
To assess whether premature rupture of membranes (PROM) is associated with placental abruption.
Design:
Population-based study.
Setting:
Data were extracted from the Medical Birth Registry of Norway.
Population:
All women with PROM (18,889 cases), including 3,077 cases of preterm premature rupture of membranes (p-PROM), among a total of 355 416 singleton births in Norway during 1999-2005 with gestational age 17-44 weeks.
Methods:
Logistic regression was used to assess whether placental abruption was associated with PROM in preterm and term births.
Main Outcome Measures:
Placental abruption.
Results:
The occurrence of placental abruption in p-PROM was higher than in the total study population, 11.0 per 1,000 (34 of 3 077) vs. 4.2 per 1 000 (1 495 of 355 416; adjusted odds ratio 2.6, 95% confidence interval 1.8-3.7). Restricting the analyses to preterm births, the occurrence of placental abruption was less in p-PROM (11.0 per 1,000) than in births without p-PROM (36.1 per 1 000; adjusted odds ratio 0.3, 95% confidence interval 0.2-0.4). In term births, no statistically significant association was observed.
Conclusions:
The findings suggest that in p-PROM the risk of placental abruption is not higher than in other preterm births; rather the opposite. However, comparing the risks in p-PROM and the total gestational age range, the present study confirmed results reported in previous studies of a higher risk of placental abruption in p-PROM than in the total birth population.
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