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Active tyrosine phosphatase in immunoprecipitates of multiple isoforms of Ly-5
M C Southey1, L J Gonez, M S Sandrin
1St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.
Abstract:
Using tumour cell lines expressing specific isoforms of murine Ly-5 (molecular weights of 180,000, 200,000 and 240,000) we find that all forms of Ly-5 and immuno-affinity purified forms of Ly-5 contain tyrosyl phosphatase activity. These results demonstrate that these isoforms of Ly-5 belong to the same family of functional receptor-linked tyrosine phosphatases as the human leukocyte common antigen. CD45.
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