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Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
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A stabilizing and denaturing dual-effect for natural polyamines interacting with G-quadruplexes depending on

Hongxia Sun1, Junfeng Xiang, Yan Liu

  • 1National Laboratory for Molecular Sciences, Center for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing, PR China.

Biochimie
|June 23, 2011
PubMed
Summary

Natural polyamines show a dual effect on G-quadruplexes, stabilizing them at low concentrations but denaturing them at high concentrations. This impacts tumor growth and proliferation research.

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