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Published on: November 7, 2020
Antibody-mediated response in rat liver chronic rejection
1Department of Hepatobiliary and Pancreatic Surgery and Center of Organ Transplantation, First Affiliated Hospital, Nanchang University, Nanchang, China.
Purpose:
The aim was to study the effect of an antibody-mediated response on rat chronic liver rejection.
Methods:
Liver transplantation was performed in rats assigned to one of the 3 treatment groups: group A, Brown Norway (BN) to BN + CsA; group B, dark Agouti (DA) to BN; and group C, DA to BN + CsA. In addition to survival and histopathologic assessment, we examined donor-specific antibodies in sera and C4d staining in the transplanted liver.
Results:
In rats with chronic rejection, high levels of IgG1 were detected from day 7, reaching peak levels at postoperative days 60-90, showing significance compared with the acute rejection (P < .05) and the syngeneic groups (P < .01). There was more C4d deposition in vessels and portal stroma of the livers from recipients displaying chronic rejection compared with recipients showing acute rejection or of syngeneic origin (P < .05).
Conclusion:
Antibody-mediated responses might play important roles in the development of chronic liver allograft rejection.