Related Experiment Video

Updated: May 31, 2026

Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging
06:08

Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging

Published on: February 7, 2014

Multiscale entropy analysis of pulse wave velocity for assessing atherosclerosis in the aged and diabetic

Hsien-Tsai Wu1, Po-Chun Hsu, Cheng-Feng Lin

  • 1Department of Electrical Engineering, National Dong Hwa University, Hualien 97401, Taiwan. dsphans@mail.ndhu.edu.tw

IEEE Transactions on Bio-Medical Engineering
|June 23, 2011
PubMed

Insights

A new dynamic pulse wave velocity (PWV) parameter, the large-scale multiscale entropy index (MEI(LS)), effectively assesses atherosclerosis progression in aging and diabetic individuals. This method surpasses traditional measures in reflecting age and blood sugar control impacts.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Physiology
  • Medical Diagnostics

Background:

  • Atherosclerosis is a significant health concern, particularly in aging and diabetic populations.
  • Traditional parameters for assessing atherosclerosis, such as pulse wave velocity (PWV), have limitations in reflecting dynamic changes.
  • There is a need for advanced methods to evaluate the progression of atherosclerosis influenced by factors like age and glycemic control.

Purpose of the Study:

  • To introduce and validate a novel dynamic PWV-based parameter, the large-scale multiscale entropy index (MEI(LS)), for assessing atherosclerosis.
  • To compare the efficacy of MEI(LS) against conventional parameters like PWV(foot) and MEI on R-R interval (MEI(RRI)).
  • To investigate the impact of age and blood sugar control on atherosclerosis progression using the MEI(LS) parameter.

Main Methods:

  • Recruited 91 subjects into four groups: young healthy, middle-aged healthy, type 2 diabetics with satisfactory glycemic control, and type 2 diabetics with unsatisfactory glycemic control.
  • Utilized self-developed six-channel electrocardiography (ECG)-PWV equipment to record PWV(foot) values over 30 minutes.
  • Analyzed PWV data using multiscale entropy (MSE) to derive the MEI(LS) as the primary assessment parameter.

Main Results:

  • The MEI(LS) parameter successfully differentiated between young healthy adults and middle-aged healthy adults.
  • Significant differences in MEI(LS) were observed between diabetic groups with satisfactory and unsatisfactory blood sugar control.
  • MEI(LS) demonstrated a superior ability to reflect the influence of age and blood sugar control on atherosclerosis progression compared to PWV(foot) and MEI(RRI).

Conclusions:

  • The dynamic MEI(LS) parameter offers a more sensitive and comprehensive assessment of atherosclerosis.
  • This novel parameter holds promise for improved monitoring and management of atherosclerosis in aging and diabetic individuals.
  • MEI(LS) provides valuable insights into the interplay between physiological aging, glycemic control, and cardiovascular health.

More Related Videos

Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome06:04

Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome

Published on: September 27, 2024

Ultrasound-based Pulse Wave Velocity Evaluation in Mice08:07

Ultrasound-based Pulse Wave Velocity Evaluation in Mice

Published on: February 14, 2017

Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Special considerations while measuring pulse01:13

Special considerations while measuring pulse

Assessing a patient's pulse is a fundamental skill in healthcare, but certain situations require special attention:
Pulse amplitude and quality01:17

Pulse amplitude and quality

Pulse amplitude is a crucial indicator of cardiac health because it provides valuable insights into the strength of left ventricular contractions and the overall uniformity of blood circulation within the vasculature. The strength of the pulse is directly related to the force with which the heart contracts and the volume of blood being pumped.
A weak or absent pulse may indicate reduced cardiac output or poor left ventricular contraction, which can be signs of cardiovascular dysfunction or...
Assessing Blood pressure using a doppler ultrasound01:19

Assessing Blood pressure using a doppler ultrasound

To obtain accurate blood pressure measurements in clinical settings, especially when traditional methods are insufficient, healthcare professionals utilize the Doppler ultrasound technique. This method uses high-frequency sound waves to detect blood flow within the arteries, which is crucial for patients with conditions that complicate circulatory system assessment.
Pre-Procedural Guidelines for Doppler Ultrasound Blood Pressure Assessment:
Preparation of Equipment:
Pulse01:16

Pulse

When the heart pumps blood out, arterial elastic fibers play a crucial role in sustaining a high-pressure gradient. They expand to accommodate the received blood and then recoil - a process known as the pulse that can be either manually palpated or electronically quantified. Despite a reduction in its effect with increased distance from the heart, elements of the pulse's systolic and diastolic components persist, observable even at the arteriole level.
The pulse serves as a clinical indicator...