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Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
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Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

Neurodevelopmental outcomes in very low-birth-weight infants in Korea: 1998-2007 vs 1989-1997

Dae-Hyun Jang1, In Young Sung, Jae Yong Jeon

  • 1Department of Rehabilitation, Incheon St Mary's Hospital, The Catholic University of Korea, Incheon, Korea.

Journal of Child Neurology
|June 23, 2011
PubMed

Insights

Survival rates for very low-birth-weight infants improved significantly, but neurodevelopmental outcomes like cerebral palsy did not change substantially over a decade. Key risk factors for cerebral palsy were identified.

Area of Science:

  • Neonatalogy
  • Pediatric Neurology
  • Developmental Pediatrics

Background:

  • Improving survival rates in very low-birth-weight (VLBW) infants is a critical goal in neonatal care.
  • Understanding long-term neurodevelopmental outcomes is essential for assessing the quality of care for VLBW infants.

Purpose of the Study:

  • To compare neurodevelopmental outcomes in VLBW infants between two distinct time periods (1989-1997 and 1998-2007).
  • To identify factors associated with adverse neurodevelopmental outcomes, specifically cerebral palsy, in VLBW infants.

Main Methods:

  • Retrospective review of medical records for VLBW infants admitted between 1998-2007 (n=824) and comparison with historical data (1989-1997, n=471).
  • Neurodevelopmental outcomes were categorized into cerebral palsy and non-cerebral palsy neurodevelopmental impairment.
  • Multivariate analysis was employed to determine risk factors for cerebral palsy.

Main Results:

  • The recent cohort showed a significantly higher survival rate (79.4% vs 66.2%) compared to the earlier cohort.
  • The incidence of cerebral palsy was lower in the recent group (7.9% vs 10.5%), though not statistically significant.
  • While non-cerebral palsy neurodevelopmental impairment was higher in the recent group (6.0% vs 4.5%), this change was not significant.
  • Survival rates increased significantly over time, but neurodevelopmental outcomes showed no significant temporal change.

Conclusions:

  • Despite improved survival, significant improvements in neurodevelopmental outcomes for VLBW infants have not been observed over the study period.
  • Abnormal neurosonographic findings, assisted ventilation, vaginal delivery, and abnormal brainstem auditory evoked potential are significant risk factors for cerebral palsy in VLBW infants.

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