Related Experiment Videos
Effect of rearing conditions on encephalomyocarditis (EMC) virus-induced diabetes in mice
K Shichinohe1, M Shimizu, M Asakawa
1Department of Laboratory Animal Science, Nippon Medical School, Tokyo, Japan.
Jikken Dobutsu. Experimental Animals
|July 1, 1990
Abstract:
To compare the incidence in the diabetic syndrome in mice reared under sterile and non-sterile conditions, both conventional and SPF DBA/2 N male mice were inoculated intraperitoneally with two doses (10(4) TCID50/0.1 ml or 10(5) TCID50/0.1 ml) of encephalomyocarditis (EMC) virus M variant. The incidence of diabetic symptoms was higher in mice reared under sterile conditions than under non-sterile conditions. It appeared that a difference in animal rearing conditions would affect the sensitivity to EMC virus in mice.