Safety and efficacy of high-dose acarbose treatment for dumping syndrome
Angela De Cunto1, Egidio Barbi, Federico Minen
1Department of Pediatrics, IRCCS Burlo Garofolo, University of Trieste, Trieste, Italy. angela.decunto@libero.it
Abstract:
Dumping syndrome (DS) is a complication of Nissen fundoplication. Dietary strategies can ameliorate symptoms, but this approach is not always foolproof. Limited evidence reports the efficacy of acarbose for children who are unresponsive to feeding manipulations. We report 8 patients with DS aged between 7 and 24 months. In 4 of 8 nutritional strategies failed, and acarbose treatment was started. The initial dose was 25 mg for meals, and increased until postprandial glucose was stable. In 3 of 4 children the final dose was higher than previously reported, without adverse effects. Acarbose is useful to treat DS in cases of failure of dietary strategies.
Related Concept Videos
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are typically...
Drugs for Treatment of Diarrhea-Predominant IBS
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Oral Hypoglycemic Agents: Biguanides and Glitazones
Acute Pancreatitis II: Clinical Manifestations and Management
Hypoglycemia and Glucagon
Oral Hypoglycemic Agents: Sulfonylureas
