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Interferon-gamma release assay performance for diagnosing tuberculosis disease in 0- to 5-year-old children

Camille Debord1, Agathe De Lauzanne, Nadège Gourgouillon

  • 1Laboratory of Immunology, Robert Debré Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris 7 Denis Diderot University, Paris, France.

The Pediatric Infectious Disease Journal
|June 23, 2011
PubMed

Insights

The QuantiFERON-TB Gold In-Tube test shows promising results for diagnosing tuberculosis in young children. Combining it with the tuberculin skin test may enhance diagnostic accuracy in this age group.

Area of Science:

  • Pediatric infectious diseases
  • Immunology
  • Diagnostic microbiology

Background:

  • Tuberculosis diagnosis in young children presents challenges.
  • Accurate and timely diagnosis is crucial for effective treatment and public health.

Purpose of the Study:

  • To evaluate the performance of the QuantiFERON-TB Gold In-Tube assay in immunocompetent children with active tuberculosis.
  • To assess the test's utility in different age subgroups of children.

Main Methods:

  • The QuantiFERON-TB Gold In-Tube test was performed on 19 immunocompetent children diagnosed with active tuberculosis.
  • Results were analyzed based on age groups: less than 2 years and 2 to 5 years.

Main Results:

  • No indeterminate results were observed in the 19 children tested.
  • The positivity rate was 6/10 in children younger than 2 years and 9/9 in children aged 2 to 5 years.

Conclusions:

  • QuantiFERON-TB Gold In-Tube demonstrates good performance in diagnosing active tuberculosis in young children.
  • The combination of QuantiFERON-TB Gold In-Tube with the tuberculin skin test may improve tuberculosis diagnosis in pediatric populations.

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