Related Experiment Video
Updated: May 31, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
Clearing the complexity: immune complexes and their treatment in lupus nephritis
Catherine Toong1, Stephen Adelstein, Tri Giang Phan
1Department of Clinical Immunology, Royal Prince Alfred Hospital, Missenden Rd, Camperdown, NSW, Australia;
Abstract:
Systemic lupus erythematosus (SLE) is a classic antibody-mediated systemic autoimmune disease characterised by the development of autoantibodies to ubiquitous self-antigens (such as antinuclear antibodies and antidouble-stranded DNA antibodies) and widespread deposition of immune complexes in affected tissues. Deposition of immune complexes in the kidney results in glomerular damage and occurs in all forms of lupus nephritis. The development of nephritis carries a poor prognosis and high risk of developing end-stage renal failure despite recent therapeutic advances. Here we review the role of DNA-anti-DNA immune complexes in the pathogenesis of lupus nephritis and possible new treatment strategies aimed at their control.
Related Concept Videos
Hypersensitivity Reactions: Immune-Complex Reactions
Nephrotic Syndrome III : Nursing Management
Nephrotic Syndrome I : Introduction
Nephrotic Syndrome II : Assessment and Medical Management
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune system...
Chronic Kidney Disease III: Interprofessional Care

